Vapaa kuvaus

Aloituksia

706

Kommenttia

3584

  1. https://www.disgenet.org/The+current+version+of+DisGeNET+(v7.0)+contains+1,134,942+gene-disease+associations+(GDAs)Tässä+selkeät+todisteet+geneettiselle+rappeutumiselle.+SNP:t+eivät+johda+evoluutioon+vaan+geneettisiin+sairauksiin.
  2. jatkuu...https://jb.asm.org/content/200/24/e00371-18"I+show+that+sites+methylated+by+the+Dcm+enzyme+exhibit+an+8-fold+increase+in+mutation+rate+in+natural+bacterial+populations.+I+also+show+that+modifications+at+other+sites+in+various+bacteria+also+increase+the+mutation+rate,+in+some+cases+by+a+factor+of+forty+or+more."https://www.cell-stress.com/researcharticles/epigenetic-mechanisms-behind-cellular-sensitivity-to-dna-damage/"The+architecture+of+the+chromatin+itself+and+its+level+of+condensation+can+greatly+impact+the+expression+of+genes+as+well+as+the+sensitivity+of+the+DNA+to+damage.""For+example,+DNA+is+more+highly+methylated,+and+therefore+compacted,+in+areas+that+contain+repetitive+sequences+to+prevent+the+expression+of+non-coding+DNA,+induction+of+double-stranded+breaks+(DSBs),+transposable+elements+and+inappropriate+recombination+events+likely+to+occur+at+repetitive+DNA+sequences.+These+events+can+lead+to+mutations,+genome+instability+and+cancer+development."https://www.labroots.com/trending/cell-and-molecular-biology/13307/warning-using-epigenetic-modifiers-therapeutic-targets"When+chromatin+is+more+'open,'+major+genetic+disruption+is+more+likely.++And+when+the+researchers+inhibited+an+epigenetic+modifier+called+G9a,+they+found+that+chromatin+accessibility,+or+openness,+increased+substantially."https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541967/"Many+studies+have+reported+that+CpG-SNPs+are+associated+with+different+diseases,+such+as+type+2+diabetes,+breast+cancer,+coronary+heart+disease,+and+psychosis+which+show+a+clear+interaction+between+genetic+(SNPs)+and+epigenetic+(DNA+methylation)+regulation."