Mäkikuismasta

Meta-analysis of effectiveness and tolerability of treatment of mild to moderate depression with St. John's Wort

Humboldt Universitat zu Berlin, Institut fur Klinische Pharmakologie.
Fortschr Neurol Psychiatr. 2004 Jun;72(6):330-43.

After anxiety, depression is one of the most common psychiatric diseases, showing a lifetime prevalence of 4 - 18 %. St. John's Wort is a herbal antidepressant combining a long tradition of use with well-proven medical research. We conducted a meta-analysis to review St. John's Wort's place in the treatment of depression. A comprehensive literature search was conducted for studies comparing effectiveness and tolerability of St. John's Wort with either placebo or synthetic antidepressant. Thirty studies met the inclusion as well as the quality criteria and were included in the meta-analysis. Four studies consisted of all three arms and were thus included in both analyses. ***Our results demonstrated a significant advantage for St. John's Wort compared to placebo. Compared to synthetic antidepressants St. John's Wort demonstrated similar effectiveness. In the sub-group of mild to moderate depression, corresponding with the indication for St. John's Wort assigned by the German health authority, the herbal antidepressant showed better results against the synthetic antidepressants. This result viewed together with St. John's Wort's favorable side-effects profile, leading to a lower rate of drop-outs, suggests treatment with St. John's Wort should be attempted for milder forms of depression.***


Surullista että Suomessa lääkebisneksen kytkökset viranomaisiin ja päättäjiin ovat siinä määrin vahvat, että mäkikuisma saatiin keploteltua täysin idioottimaisin ja harhaanjohtavin keinoin apteekkeihin - ja jopa sinnekin täysin ylihinnoiteltuna ja alitehoisena valmisteena. Hyvä Suomi! Onneksi sivistysmaista saa hyvälaatuista ja tehokasta mäkikuismaa. Saksassahan tämä pitkät perinteet omaava pehmeästi hoitava rohdoskasvi on eniten myyty antidepressantti. Eikö sen pitäisi kertoa jollekin jotain? Niin on maissa ja ihmisten hoidossa eroja...