Cannabidiol and (-)Delta 9-tetrahydrocannabinol are neuroprotective antioxidants
Hampson AJ, Grimaldi M, Axelrod J, Wink D
Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8268-73.
Laboratory of Cellular and Molecular Regulation, National Institutes of Mental Health, Bethesda, MD 20892, USA.
Koko artikkeli ja kuvat:
http://www.pubmedcentral.gov/articlerender.fcgi?tool=pubmed&pubmedid=9653176
"The neuroprotection observed with cannabidiol and THC was unaffected by cannabinoid receptor antagonist, indicating it to be cannabinoid receptor independent. Previous studies have shown that glutamate toxicity may be prevented by antioxidants. Cannabidiol, THC and several synthetic cannabinoids all were demonstrated to be antioxidants by cyclic voltametry. Cannabidiol and THC also were shown to prevent hydroperoxide-induced oxidative damage as well as or better than other antioxidants in a chemical (Fenton reaction) system and neuronal cultures. Cannabidiol was more protective against glutamate neurotoxicity than either ascorbate or alpha-tocopherol, indicating it to be a potent antioxidant. These data also suggest that the naturally occurring, nonpsychotropic cannabinoid, cannabidiol, may be a potentially useful therapeutic agent for the treatment of oxidative neurological disorders such as cerebral ischemia."
Hampson AJ, Grimaldi M, Axelrod J, Wink D
Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8268-73.
Laboratory of Cellular and Molecular Regulation, National Institutes of Mental Health, Bethesda, MD 20892, USA.
Koko artikkeli ja kuvat:
http://www.pubmedcentral.gov/articlerender.fcgi?tool=pubmed&pubmedid=9653176
"The neuroprotection observed with cannabidiol and THC was unaffected by cannabinoid receptor antagonist, indicating it to be cannabinoid receptor independent. Previous studies have shown that glutamate toxicity may be prevented by antioxidants. Cannabidiol, THC and several synthetic cannabinoids all were demonstrated to be antioxidants by cyclic voltametry. Cannabidiol and THC also were shown to prevent hydroperoxide-induced oxidative damage as well as or better than other antioxidants in a chemical (Fenton reaction) system and neuronal cultures. Cannabidiol was more protective against glutamate neurotoxicity than either ascorbate or alpha-tocopherol, indicating it to be a potent antioxidant. These data also suggest that the naturally occurring, nonpsychotropic cannabinoid, cannabidiol, may be a potentially useful therapeutic agent for the treatment of oxidative neurological disorders such as cerebral ischemia."
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