Inositoli voi auttaa PCOS:ia saiastavia:
Inositol and polycystic ovary syndrome
Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial.
Eur Rev Med Pharmacol Sci. 2003 Nov-Dec;7(6):151-9.
Women with oligomenorrhea and polycystic ovaries show a high incidence of ovulation failure perhaps linked to insulin resistance and related metabolic features. A small number of reports shows that inositol improves ovarian function. The aim of this study was to use a double-blind, placebo-controlled approach with detailed assessment of ovarian activity to assess the validity of this therapeutic approach in this group of women. Of the 283 patients randomized, 2 withdrew before treatment commenced, 147 received placebo, and 136 received inositol (100 mg, twice a day). The ovulation frequency estimated by the ratio of luteal phase weeks to observation weeks was significantly higher in the treated group (23%) compared with the placebo (13%). The time in which the first ovulation occurred was significantly shorter. The number of patients failing to ovulate during the placebo-treatment period was higher in the placebo group, and in most cases ovulations were characterized by normal progesterone concentrations in both groups. The effect of inositol on follicular maturation was rapid, because the circulating concentration of E2 increased only in the inositol group during the first week of treatment. Significant weight loss (and leptin reduction) was recorded in the inositol group, whereas in the placebo group was recorded an increase of the weight. No change in fasting glucose concentrations, fasting insulin, or insulin responses to glucose challenge test was recorded after 14-wk of inositol and placebo therapy. There was an inverse relationship between body mass of the patients and the efficacy of the treatment. These data support a beneficial effect of inositol in improving ovarian function in women with oligomenorrhea and polycystic ovaries.
Inositol and polycystic ovary syndrome
Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial.
Eur Rev Med Pharmacol Sci. 2003 Nov-Dec;7(6):151-9.
Women with oligomenorrhea and polycystic ovaries show a high incidence of ovulation failure perhaps linked to insulin resistance and related metabolic features. A small number of reports shows that inositol improves ovarian function. The aim of this study was to use a double-blind, placebo-controlled approach with detailed assessment of ovarian activity to assess the validity of this therapeutic approach in this group of women. Of the 283 patients randomized, 2 withdrew before treatment commenced, 147 received placebo, and 136 received inositol (100 mg, twice a day). The ovulation frequency estimated by the ratio of luteal phase weeks to observation weeks was significantly higher in the treated group (23%) compared with the placebo (13%). The time in which the first ovulation occurred was significantly shorter. The number of patients failing to ovulate during the placebo-treatment period was higher in the placebo group, and in most cases ovulations were characterized by normal progesterone concentrations in both groups. The effect of inositol on follicular maturation was rapid, because the circulating concentration of E2 increased only in the inositol group during the first week of treatment. Significant weight loss (and leptin reduction) was recorded in the inositol group, whereas in the placebo group was recorded an increase of the weight. No change in fasting glucose concentrations, fasting insulin, or insulin responses to glucose challenge test was recorded after 14-wk of inositol and placebo therapy. There was an inverse relationship between body mass of the patients and the efficacy of the treatment. These data support a beneficial effect of inositol in improving ovarian function in women with oligomenorrhea and polycystic ovaries.
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