http://www.epa.gov/iaq/pubs/hpguide.html#hypersensitivity pneumonitis:
>> Hypersensitivity Pneumonitis
Another class of hypersensitivity disease is hypersensitivity pneumonitis, which may include humidifier fever. Hypersensitivity pneumonitis, also called allergic alveo-litis, is a granulomatous interstitial lung disease caused by exposure to airborne antigens. It may affect from one to five percent or more of a specialized population exposed to appropriate antigens (e.g., farmers and farmers' lung, pigeon breeders and pigeon breeders' disease)37. Continued antigen exposure may lead to end-stage pulmonary fibrosis. Hypersensitivity pneumonitis is frequently misdiagnosed as a pneumonia of infectious etiology. The prevalence of hypersensitivity pneumonitis in the general population is unknown.
Outbreaks of hypersensitivity pneumonitis in office buildings have been traced to air conditioning and humidification systems contaminated with bacteria and molds38. In the home, hypersensitivity pneumonitis is often caused by contaminated humidifiers or by pigeon or pet bird antigens. The period of sensitization before a reaction occurs may be as long as months or even years. Acute symptoms, which occur four to six hours postexposure and recur on challenge with the offending agent, include cough, dyspnea, chills, myalgia, fatigue, and high fever. Nodules and nonspecific infiltrates may be noted on chest films. The white blood cell count is elevated, as is specific IgG to the offending antigen. Hypersensitivity pneumonitis generally responds to corticosteroids or cessation of exposure (either keeping symptomatic people out of contaminated environments or removing the offering agents).
>> Hypersensitivity Pneumonitis
Another class of hypersensitivity disease is hypersensitivity pneumonitis, which may include humidifier fever. Hypersensitivity pneumonitis, also called allergic alveo-litis, is a granulomatous interstitial lung disease caused by exposure to airborne antigens. It may affect from one to five percent or more of a specialized population exposed to appropriate antigens (e.g., farmers and farmers' lung, pigeon breeders and pigeon breeders' disease)37. Continued antigen exposure may lead to end-stage pulmonary fibrosis. Hypersensitivity pneumonitis is frequently misdiagnosed as a pneumonia of infectious etiology. The prevalence of hypersensitivity pneumonitis in the general population is unknown.
Outbreaks of hypersensitivity pneumonitis in office buildings have been traced to air conditioning and humidification systems contaminated with bacteria and molds38. In the home, hypersensitivity pneumonitis is often caused by contaminated humidifiers or by pigeon or pet bird antigens. The period of sensitization before a reaction occurs may be as long as months or even years. Acute symptoms, which occur four to six hours postexposure and recur on challenge with the offending agent, include cough, dyspnea, chills, myalgia, fatigue, and high fever. Nodules and nonspecific infiltrates may be noted on chest films. The white blood cell count is elevated, as is specific IgG to the offending antigen. Hypersensitivity pneumonitis generally responds to corticosteroids or cessation of exposure (either keeping symptomatic people out of contaminated environments or removing the offering agents).
Vastaukset 2
Vanhimmat
http://images.google.fi/imgres?imgurl=http://upload.wikimedia.org/wikipedia/commons/thumb/e/e6/Heart-and-lungs.jpg/180px-Heart-and-lungs.jpg&imgrefurl=http://fi.wikipedia.org/wiki/Keuhkot&usg=__nCIzdoWT8ItBzsY9bQIqgB0tuv8=&h=176&w=180&sz=13&hl=fi&start=5&um=1&tbnid=gj2cfKknHeKrhM:&tbnh=99&tbnw=101&prev=/images?q=keuhkojen pleura&hl=fi&lr=lang_fi&sa=G&um=1
"Idiopaattinen keuhkofibroosi (IPF, tunnetaan myös nimillä idiopaattinen fibrotisoiva interstitiaalinen pneumonia ja fibrotisoiva alveoliitti) on keuhkoparenkyymisairauksiin kuuluva keuhkotauti. Sen aiheuttaja on tuntematon. Taudin oireina ovat yskä, hengenahdistus ja kuumeilu, jotka ovat luonteeltaan epämääräisiä ja pitkään kestäneitä. IPF johtaa muutamassa vuodessa vaikean fibroosin eli sidekudosmuodostumisen kehittymiseen ja on huonoennusteinen tauti. Sairauden ilmaantuvuus on noin 7–10/100 000.[1]
Idiopaattista keuhkofibroosia sairastavan henkilön keuhkokudoksesta otetussa koepalassa nähdään muutoksia, joiden histopatologinen termi on UIP (usual interstitial pneumonia). Keuhkokudoksessa eli keuhkorakkuloiden välisessä tilassa havaitaan honeycomb-tyyppisiä verkkomaisia muutoksia, fibroblastien liiallista jakautumista ja sidekudosmuodostusta. Tulehdusreaktio on vähäistä.[2]
Idiopaattisen keuhkofibroosin hoidosta ei ole selkeää linjausta. Hoito kortikosteroideilla ei liene tehokasta, koska sairaudessa ei ole mukana tulehdusreaktiota. Solunsalpaajia on kokeiltu taudin hoidossa, mutta niiden tehosta ei ole varmuutta. Joissain tapauksissa voidaan harkita keuhkonsiirtoa.[1]"
http://images.google.fi/imgres?imgurl=http://www.uku.fi/~psipola/CMRI_normaaliarvot.jpg&imgrefurl=http://www.uku.fi/~psipola/&usg=__C0pYn1mMCUN8Rb8Qif2sak9VTEs=&h=720&w=960&sz=115&hl=fi&start=10&um=1&tbnid=bf6p8AlXydAFiM:&tbnh=111&tbnw=148&prev=/images?q=keuhkojen pleura&hl=fi&lr=lang_fi&sa=G&um=1