Paljastettiin nyt uutisissa!
http://www.reuters.com/article/idUSTRE62K1BK20100321
Nanotech robots deliver gene therapy through blood
(Reuters) - U.S. researchers have developed tiny nanoparticle robots that can travel through a patient's blood and into tumors where they deliver a therapy that turns off an important cancer gene.
The finding, reported in the journal Nature on Sunday, offers early proof that a new treatment approach called RNA interference or RNAi might work in people.
RNA stands for ribonucleic acid -- a chemical messenger that is emerging as a key player in the disease process.
Dozens of biotechnology and pharmaceutical companies including Alnylam, Merck, Pfizer, Novartis and Roche are looking for ways to manipulate RNA to block genes that make disease-causing proteins involved in cancer, blindness or AIDS.
But getting the treatment to the right target in the body has presented a challenge.
A team at the California Institute of Technology in Pasadena used nanotechnology -- the science of really small objects -- to create tiny polymer robots covered with a protein called transferrin that seek out a receptor or molecular doorway on many different types of tumors.
"This is the first study to be able to go in there and show it's doing its mechanism of action," said Mark Davis, a professor of chemical engineering, who led the study.
"We're excited about it because there is a lot of skepticism whenever any new technology comes in," said Davis, a consultant to privately held Calando Pharmaceuticals Inc, which is developing the therapy.
Other teams are using fats or lipids to deliver the therapy to the treatment target. Pfizer last week announced a deal with Canadian biotech Tekmira Pharmaceuticals Corp for this type of delivery vehicle for its RNAi drugs, joining Roche and Alnylam.
In the approach used by Davis and colleagues, once the particles find the cancer cell and get inside, they break down, releasing small interfering RNAs or siRNAs that block a gene that makes a cancer growth protein called ribonucleotide reductase.
"In the particle itself, we've built what we call a chemical sensor," Davis said in a telephone interview. "When it recognizes that it's gone inside the cell, it says OK, now it's time to disassemble and give off the RNA."
In a phase 1 clinical trial in patients with various types of tumors, the team gave doses of the targeted nanoparticles four times over 21 days in a 30-minute intravenous infusion.
Tumor samples taken from three people with melanoma showed the nanoparticles found their way inside tumor cells.
And they found evidence that the therapy had disabled ribonucleotide reductase, suggesting the RNA had done its job.
Davis could not say whether the therapy helped shrink tumors in the patients, but one patient did get a second cycle of treatment, suggesting it might be. Nor could he say if there were any safety concerns.
Davis said that part of the study will be presented at the American Society of Clinical Oncology meeting in June.
http://www.reuters.com/article/idUSTRE62K1BK20100321
Nanotech robots deliver gene therapy through blood
(Reuters) - U.S. researchers have developed tiny nanoparticle robots that can travel through a patient's blood and into tumors where they deliver a therapy that turns off an important cancer gene.
The finding, reported in the journal Nature on Sunday, offers early proof that a new treatment approach called RNA interference or RNAi might work in people.
RNA stands for ribonucleic acid -- a chemical messenger that is emerging as a key player in the disease process.
Dozens of biotechnology and pharmaceutical companies including Alnylam, Merck, Pfizer, Novartis and Roche are looking for ways to manipulate RNA to block genes that make disease-causing proteins involved in cancer, blindness or AIDS.
But getting the treatment to the right target in the body has presented a challenge.
A team at the California Institute of Technology in Pasadena used nanotechnology -- the science of really small objects -- to create tiny polymer robots covered with a protein called transferrin that seek out a receptor or molecular doorway on many different types of tumors.
"This is the first study to be able to go in there and show it's doing its mechanism of action," said Mark Davis, a professor of chemical engineering, who led the study.
"We're excited about it because there is a lot of skepticism whenever any new technology comes in," said Davis, a consultant to privately held Calando Pharmaceuticals Inc, which is developing the therapy.
Other teams are using fats or lipids to deliver the therapy to the treatment target. Pfizer last week announced a deal with Canadian biotech Tekmira Pharmaceuticals Corp for this type of delivery vehicle for its RNAi drugs, joining Roche and Alnylam.
In the approach used by Davis and colleagues, once the particles find the cancer cell and get inside, they break down, releasing small interfering RNAs or siRNAs that block a gene that makes a cancer growth protein called ribonucleotide reductase.
"In the particle itself, we've built what we call a chemical sensor," Davis said in a telephone interview. "When it recognizes that it's gone inside the cell, it says OK, now it's time to disassemble and give off the RNA."
In a phase 1 clinical trial in patients with various types of tumors, the team gave doses of the targeted nanoparticles four times over 21 days in a 30-minute intravenous infusion.
Tumor samples taken from three people with melanoma showed the nanoparticles found their way inside tumor cells.
And they found evidence that the therapy had disabled ribonucleotide reductase, suggesting the RNA had done its job.
Davis could not say whether the therapy helped shrink tumors in the patients, but one patient did get a second cycle of treatment, suggesting it might be. Nor could he say if there were any safety concerns.
Davis said that part of the study will be presented at the American Society of Clinical Oncology meeting in June.
Vastaukset 17
Vanhimmat
Hienoa, että lääketiede etenee ja kehittää yhä uusia tapoja taistella tauteja vastaan ja pelastaa ihmishenkiä toivottomaltakin vaikuttaneesta tilanteesta, mutta miten tämä liittyy pandemioihin?
Pillerien ja piikkien myynnin edistämisen puolesta, vai onko havainnot vain "näköharhaa", ja tapahtumat sattumaa?
Eli mielestäsi lääketiedettä ei kannata kehittää, vaan antaa sairaiden kärsiä ja kuolla vaan, ilman toivoa uudesta lääkkeestä tai hoitotavasta, joka voisi tämän onnettoman vielä pelastaa elämälle?
Tulihan se "bisnesmiehen" näkökulma sieltä jälleen esiin!
Syvennypä esim. tuohon:
http://www.mtv3.fi/uutiset/kotimaa.shtml/arkistot/kotimaa/2009/11/999088
Eli pidät syöpää täysin lääketeollisuuden tuotteistamana tautina, jota ei pidä diagnosoida saati hoitaa ja lääkitä?
Kirvesvartta!
On huono esimerkki. Sanakin tulee Wanhasta Suomesta ja sillä tarkoitettiin ihmistä syövää tautia, joka kuihdutti ts. söi ihmisen ennen kuolemaa.
Mutta kun syövän taudin lisäksi ennen ei ollut juuri muita kuin rintatauti, vatsatauti ja rokko, joihin ihmiset kuolivat, niin kyllähän lääketeollisuus on nykyään tuotteistanut tauteja.
"Niin terveen näköinen iso punakka mies ja kaatui seisovilta jaloiltaan", kuten ennen sanottiin. Ei silloin "Wanhaan Hyvään Aikaan" mitään Wiruksia ja Pakteereita ollut. Ihmiset elivät sen neljäkymmentä vuotta minkä Luoja soi ja kuolivat pois.
Turhaan sinäkin Minaattorin Kolli täällä vaahtoat.
Sitä vaahtoa löytyy ennemminkin täällä riehuvien paranoidien salaliittohörhöjen suupielistä. ; )
Minä vain kyseenalaistan typeryyksiä. Saamatta typeryksiltä koskaan kunnon vastausta...
jäävät usein esittäjän ratkaistaviksi!
pelimerkkejä on havaittu sikapruutassa.
http://www2.dyn.fi/541638679
kummaa, ettei linkki aukene meille.
http://tinyurl.com/y8jlkxm
Missä kohdassa sinä näit puhuttavan nanosiruista?
Nanosiru/nano(partikkeliro)botti = sama asia ainakin näin puhekielessä.
"U.S. researchers have developed tiny nanoparticle robots"
Pandemioihin tämä liittyy siksi, että tälläkin palstalla sikapiikin on huhuttu olevan nanorokote.
http://nwohavaintoja.blogspot.com/2009/12/pandemrix-rokote-on-tappava-nanorokote.html
Rautalangasta: kaikkea, kuten myös tällaista teknologiaa voi käyttää hyvään ja pahaan tarkoitukseen. Kuinka monesti historian aikana herrat ovat vetäneet meitä nenästä? Eikö ole mahdollista, että se tapahtuu taas?
Nimimerkille"totisen totta" haluan vain vääntää rautalangasta että "huhut" ei ole sama asia kuin "totisen totta". Voisin vetää sinulle paljon muutakin rautalangasta, mutta taitaisi olla rautalangan väärinkäyttöä käyttää sitä sinun kaltaiseen älyvapaaseen tapaukseen.
Itse tarjosin sinulle useita mahdollisuuksia selittää asiasi ja vetäytyä vastuusta alunperin kirjoittamaasi, ettei sinua porukka alkaisi luulla paranoidiksi salaliittohihhuliksi, mutta näköjään vaivauduin turhaan, koska sinähän _olet_ paranoidi salaliittohihhuli. ; )
hallitaan nanosiruilla.
http://keskustelu.kauppalehti.fi/5/i/keskustelu/thread.jspa?threadID=140606&tstart=0
Tuon pakkomielteen alituinen jauhaminen päässäsi ei ainakaan paranna tilasi prognoosia.