myasthenia graviksen rosuvastatin

https://www.terveyskirjasto.fi/dlk00911#s2


Seuraavat lääkkeet voivat pahentaa oireita, joten niiden käytössä noudatetaan varovaisuutta:
beetasalpaajat (verenpaine- ja sydänlääkkeitä)
kalsiuminestäjät (verenpaine- ja sydänlääkkeitä)
tietyt antibiootit
jotkin psyykenlääkkeet
jotkin aivojen kautta vaikuttavat kipulääkkeet
statiinit (kolesterolilääkkeitä).

https://pmc.ncbi.nlm.nih.gov/articles/PMC2670554/

STATINS MAY AGGRAVATE MYASTHENIA GRAVIS

As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health.
Learn more: PMC Disclaimer | PMC Copyright Notice
NIHPA Author Manuscripts logo
Muscle Nerve. Author manuscript; available in PMC: 2009 Apr 20.
Published in final edited form as: Muscle Nerve. 2008 Sep;38(3):1101–1107. doi: 10.1002/mus.21074
STATINS MAY AGGRAVATE MYASTHENIA GRAVIS
SHIN J OH 1, ROHIT DHALL 1, ANGELA YOUNG 1, MARLA B MORGAN 1, LIANG LU 1, GWENDOLYN C CLAUSSEN 1
Author information
Copyright and License information
PMCID: PMC2670554 NIHMSID: NIHMS94456 PMID: 18720508
The publisher's version of this article is available at Muscle Nerve
Abstract
Statin-induced myopathy is well-known, but the effect of cholesterol-lowering agents on myasthenia gravis (MG) has not been studied in detail. We investigated statin use and its effects on MG among patients with this disease. Statin information was systemically obtained from 170 patients being treated at the Neuromuscular Disease Clinic at the University of Alabama at Birmingham. When a new myalgic syndrome or worsening of MG developed within 4 months after statin treatment, no other likely cause was found, and clinical improvement occurred either with or without discontinuation of the statin, we considered these symptoms to be statin-induced. Fifty-four patients (31%) were on statins. The statin group had proportionally more males, and older patients compared with the non-statin group. A myalgic syndrome was noted in 7 (13%) patients, but it resolved without any sequelae after withdrawal of the statin. MG worsening occurred in 6 (11%) patients without regard to type of MG or brand of statin. MG worsening occurred independently of myalgic syndrome and involved predominantly oculobulbar symptoms within 1-16 weeks of statin treatment. In 4 patients, additional treatment was needed to reverse MG worsening. Statins are safe in the majority of MG patients, but their use must be accompanied by close observation for possible MG worsening.

Keywords: drug side effect, HMG coenzyme A reductase inhibitor, myasthenia gravis, myotoxicity, statin

Statins [3-hydroxy-3-methylglutaryl (HMG) coenzyme A reductase inhibitors] are known to reduce serum low-density lipoprotein (LDL) by inhibiting HMG coenzyme A reductase. In recent years, they have been used widely in the treatment of hypercholesterolemia. Their side effects on muscle are well known and range from myalgia and muscle cramp to elevation of creatine kinase (CK), myopathy, and rhabdodomyolysis.13,17 It is also known that statins may unmask underlying neuromuscular diseases.1,16,19 There have been a few case reports of worsening of myasthenia gravis (MG) in patients treated with statins.3,9,12 However, their effect on MG has not been studied systematically. We investigated the use of statins and their effects on MG among our patients.

METHODS
The diagnosis of MG was made when fluctuating clinical weakness was present and at least one of four laboratory tests [acetylcholine receptor antibody (AChR-ab), muscle-specific protein tyrosine kinase antibody (MuSK-ab), repetitive nerve stimulation (RNS) test, or single-fiber electromyography (SFEMG)] was abnormal.8

To assess the adverse muscular side effects of statins in MG, we added “MG worsening” to the ACC/AHA/NHLBI classification in statin-induced muscular adverse events.10 The ACC/AHA/NHLBI classification includes the myalgic syndrome (muscle aches with normal CK), myositis (muscle symptoms with elevated CK), and rhabdomyolysis (muscle symptoms with CK >10 times the upper limit of normal and creatinine elevation).10 MG worsening is defined as worsening or relapse of any MG symptoms. Because we did not have any patients with myositis or rhabdomyolysis in our study, we used only two adverse side effects in our

KuvaMyastenia Kaavakuva siitä, miten myastenian oireet jakautuvat eri lihasryhmiin. A-sarake kertoo, kuinka usein kyseiset lihasryhmät ovat vaurioituneet jo sairauden alussa. B-sarake kertoo vaurioiden yleisyyden lihasryhmissä myöhemmin sairauden kuluessa. Alussa silmäluomien lihakset ja silmänliikuttajalihakset oireilevat yleisimmin, myöhemmin muut lihasryhmät tulevat mukaan. Lisää tietoa lihastaudeista, ks. Lihastaudit.

silmämyastenia


https://laakeinfo.fi/Medicine.aspx?m=18347

Esiintymistiheys tuntematon (koska saatavissa oleva tieto ei riitä arviointiin):

ripuli
yskä
hengenahdistus
edeema (turvotus)
unihäiriöt, mukaan lukien unettomuus ja painajaiset
seksuaaliset ongelmat
masennus
hengitysvaikeudet, mukaan lukien jatkuva yskä ja/tai hengenahdistus tai kuume
jännevaurio
jatkuva lihasheikkous
myasthenia gravis (sairaus, joka aiheuttaa yleistä lihasheikkoutta, joissakin tapauksissa myös hengityslihaksissa)
silmämyastenia (silmän lihasten heikkoutta aiheuttava sairaus).

Yhteenveto kolesterolilääkkeistä: ovat erittäin haitallisia.
Lopetin niien käytön 3p sitten

Kivulias erektio.