Jos sähköshokki on auttavinaan masennukseen ja ahdistukseen, niin ketamiini tekee saman vielä kivuttomammin, turvallisemmin ja paljon tehokkaammin. Venäläisen tutkimuksen mukaan ketamiinilla on pitkäkestoinen myönteinen vaikutus mielenterveyteen, isoilla annoksilla 6 kk ja pienemmilläkin 1 kk. Suurella annoksella ketamiinia tyypillisesti voi mm. sulautua kosmokseen, kohdata jumalan, kokea syntyvänsä uudelleen ym, ja sellaisen jälkeen olo on kuin vastakuoriutuneella kananpojalla, maalliset ongelmat tuntuvat pienemmiltä ja myönteinen vaikutus kestää kauan.
Venäläisessä tutkimuksessa selvitettiin ketamiinin käyttöä heroiiniriippuvuuden hoidossa, mutta siinä sivussa havaittiin myös myönteiset vaikutukset mielenterveyteen.
http://www.maps.org/news-letters/v09n4/09421kru.html
KETAMINE ASSISTED PSYCHOTHERAPY (KPT) OF HEROIN ADDICTION:
IMMEDIATE EFFECTS AND SIX MONTHS FOLLOW-UP
Krupitsky E.M., Burakov A.M., Romanova T.N., Grinenko A.Y., Strassman R.J.
St.Petersburg Scientific Research Center of Addictions and Psychopharmacology affiliated with St.Petersburg State Pavlov Medical University
Leningrad Regional Center of Addictions, Novo-Deviatkino 19/1, Leningrad Region 188661, Russia. E-mail: [email protected].
"KPT influence on personality
KPT in the experimental group produced a decrease in scores for the following MMPI scales: depression, conversion hysteria, paranoia, schizophrenia, and Taylor scale of anxiety. The self- sufficiency score significantly increased after KPT. On the whole, such favorable psychological dynamics suggest that patients became more sure of themselves, their possibilities and their futures, less anxious, less depressed and neurotic, and more emotionally open after KPT. These changes are very similar to those noted in alcoholics after KPT (Krupitsky and Grinenko, 1997) and are favorable for abstinence. KPT in the control group decreased scores of the following scales hypochondriasis, depression, conversion hysteria, masculinity-femininity, paranoia, psychasthenia, schizophrenia, sensitivity-repression, and Taylor scale of anxiety. The self- sufficiency score significantly increased after KPT. Positive MMPI changes in the control group were similar to those in the experimental group and included even more scales."
"KPT influence on understanding the meaning and purpose of one's own life
KPT influence on understanding the meaning of one's own life was assessed using the Purpose- in-Life Test (PLT) based on Frankl's (1978) concept of the individual's aspiration for meaning in life. The PLT was adapted in Russian by Leontiev (1992). KPT caused a significant increase in the indices measuring understanding the meanings and purposes in life, as well as self- actualization, and the ability to control oneself and one's own life in accordance to those life purposes. PLT changes after KPT were similar in both groups. This means that after KPT (regardless of the ketamine dose) patients were better able to understand the meaning of their lives, their life purposes, and perspective. After KPT, their lives became more interesting, emotionally deeper, and filled with meaning. They felt themselves better able to live in accordance with their concept of the meaning of life and life purposes as a result of KPT. "
Aiheesta on tehty toinenkin tutkimus, josta löytyi pelkkä lyhyt kuvaus mutta ei koko tekstiä:
Antidepressant effects of ketamine in depressed patients
Investigators: Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS, Krystal JH
Abraham Ribicoff Center Clinical Neuroscience Research Unit of theConnecticut Mental Health Center, New Haven 06519, USA
Seven subjects with major depression completed 2 test days that involved intravenous treatment with ketamine hydrochloride (.5 mg/kg) or saline solutions under randomized, double-blind conditions. RESULTS: Subjects with depression evidenced significant improvement indepressive symptoms within 72 hours after ketamine but not placebo infusion. CONCLUSIONS: These results suggest a potential role for NMDA receptor-modulating drugs in the treatment of depression.
Last updated: Wed Apr 12 2000
* Reference: Biol Psychiatry 2000 Feb 15;47(4):351-4.
Venäläisessä tutkimuksessa selvitettiin ketamiinin käyttöä heroiiniriippuvuuden hoidossa, mutta siinä sivussa havaittiin myös myönteiset vaikutukset mielenterveyteen.
http://www.maps.org/news-letters/v09n4/09421kru.html
KETAMINE ASSISTED PSYCHOTHERAPY (KPT) OF HEROIN ADDICTION:
IMMEDIATE EFFECTS AND SIX MONTHS FOLLOW-UP
Krupitsky E.M., Burakov A.M., Romanova T.N., Grinenko A.Y., Strassman R.J.
St.Petersburg Scientific Research Center of Addictions and Psychopharmacology affiliated with St.Petersburg State Pavlov Medical University
Leningrad Regional Center of Addictions, Novo-Deviatkino 19/1, Leningrad Region 188661, Russia. E-mail: [email protected].
"KPT influence on personality
KPT in the experimental group produced a decrease in scores for the following MMPI scales: depression, conversion hysteria, paranoia, schizophrenia, and Taylor scale of anxiety. The self- sufficiency score significantly increased after KPT. On the whole, such favorable psychological dynamics suggest that patients became more sure of themselves, their possibilities and their futures, less anxious, less depressed and neurotic, and more emotionally open after KPT. These changes are very similar to those noted in alcoholics after KPT (Krupitsky and Grinenko, 1997) and are favorable for abstinence. KPT in the control group decreased scores of the following scales hypochondriasis, depression, conversion hysteria, masculinity-femininity, paranoia, psychasthenia, schizophrenia, sensitivity-repression, and Taylor scale of anxiety. The self- sufficiency score significantly increased after KPT. Positive MMPI changes in the control group were similar to those in the experimental group and included even more scales."
"KPT influence on understanding the meaning and purpose of one's own life
KPT influence on understanding the meaning of one's own life was assessed using the Purpose- in-Life Test (PLT) based on Frankl's (1978) concept of the individual's aspiration for meaning in life. The PLT was adapted in Russian by Leontiev (1992). KPT caused a significant increase in the indices measuring understanding the meanings and purposes in life, as well as self- actualization, and the ability to control oneself and one's own life in accordance to those life purposes. PLT changes after KPT were similar in both groups. This means that after KPT (regardless of the ketamine dose) patients were better able to understand the meaning of their lives, their life purposes, and perspective. After KPT, their lives became more interesting, emotionally deeper, and filled with meaning. They felt themselves better able to live in accordance with their concept of the meaning of life and life purposes as a result of KPT. "
Aiheesta on tehty toinenkin tutkimus, josta löytyi pelkkä lyhyt kuvaus mutta ei koko tekstiä:
Antidepressant effects of ketamine in depressed patients
Investigators: Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS, Krystal JH
Abraham Ribicoff Center Clinical Neuroscience Research Unit of theConnecticut Mental Health Center, New Haven 06519, USA
Seven subjects with major depression completed 2 test days that involved intravenous treatment with ketamine hydrochloride (.5 mg/kg) or saline solutions under randomized, double-blind conditions. RESULTS: Subjects with depression evidenced significant improvement indepressive symptoms within 72 hours after ketamine but not placebo infusion. CONCLUSIONS: These results suggest a potential role for NMDA receptor-modulating drugs in the treatment of depression.
Last updated: Wed Apr 12 2000
* Reference: Biol Psychiatry 2000 Feb 15;47(4):351-4.
Vastaukset 4
Vanhimmat
Mikä ihmeen ketamiini?
käytetään (valitettavasti!) huumeena.
Just...
Runsas annos ketamiinia tuntuu lahes yhta miellyttavalta kun valiaikainen halvaantuminen aivot mukaanlukien.
Jos kiitollisuus normaalitilaan palaamisesta parantaa jonkun masennuksen niin jippijaijee! -Go ahead -mutta en suosittelis hoitometodin kayttamista joka on niin paskamainen, etta huojennus hoitokarmeuden lopettamisesta toimisi masennustilan parantajana...
ei vittu