prepulsid

Olen käyttänyt monta vuotta sitten mutta tutkin lääkettä kolme vuotta sitten, kun lääkäri sanoi että uskaltaisiko määrätä mutta ei sanonut miksi. USA:ssa sen myynti lopetettiin samoin kuin Kanadassa sillä prepulsid on aiheuttanut monia vakavia sydänperäisiä kuolemia. Otin alla olevan tekstin netistä.

PREPULSID (cisapride)

Health Canada would like to advise you that the prokinetic drug, PREPULSID (cisapride), will no longer be available from pharmacies effective August 7, 2000. PREPULSID, marketed by Janssen-Ortho Inc., is a prescription drug indicated for the treatment of gastroparesis, intestinal pseudo-obstruction, and gastroesophageal reflux disease which is refractory to lifestyle modifications, antacids, and gastric acid reducing agents. The decision to withdraw PREPULSID from the market is founded on the association of the drug with serious cardiac arrhythmias (e.g. ventricular tachycardia, torsades de pointes, and ventricular fibrillation) and sudden cardiac deaths. Between its introduction in 1990 and February 2000, Health Canada received at least 44 spontaneous domestic reports of potential cardiac rhythm abnormalities associated with PREPULSID, including at least 10 reports of death. In the United States, the Food and Drug Administration has received 341 reports of cardiac rhythm abnormalities, including 80 fatalities. The continuing occurrence of such adverse events, despite several letters to health care professionals and changes to the Product Monograph, has led to the conclusion that the risks associated with PREPULSID are not manageable in the setting of licensed drug use.

Health Canada advises physicians who currently have patients on PREPULSID (cisapride) to contact these patients as soon as possible and establish whether their conditions can be treated with other therapies (e.g. lifestyle modifications, acid suppression, surgery, etc.). Pharmacists dispensing PREPULSID should advise patients to immediately contact their prescribing physicians to develop an appropriate treatment plan.

May 31, 2000

Warning

PREPULSID® to be withdrawn as a result of cardiac complications

OTTAWA - Health Canada is warning consumers who are using the
drug, PREPULSID® (cisapride), of the possibility of rare, but
serious, heart complications, including arrhythmias (irregular
heartbeat rhythms) and sudden death. Consumers using the drug
are advised to contact their physicians as soon as possible to
discuss alternative treatments.

PREPULSID® is used to treat gastro-esophageal reflux
(heartburn), gastroparesis (inability of the stomach to empty
properly), and other disorders of gastrointestinal movement.

PREPULSID® is a prescription drug, marketed by Janssen-Ortho
Inc. Health Canada is requiring that Janssen-Ortho Inc. stop sale of
this product. Effective August 7, 2000, the product will no longer be
available from pharmacies. The manufacturer has also announced
its intention to discontinue marketing of the drug in the United
States.

..edes Suomen markkinoilla taida olla! Ainakaan lääkelaitos ei löytänyt lääkettä.

Nelivuotias tyttäreini sai refluksitautiin nestemäistä Prepulsidia erityisluvalla. Ei ole käyttänyt sitäkään enää puoleen vuoteen.