Imovane ja Stilnoct syöpävaarallisia

määrätään yleensä unettomuuden lyhytaikaiseen hoitoon....

Täytyy perehtyä tuohon farmakokinetiikkaan tarkemmin, en vielä hoksannut karsinogeenisuuden syytä. Lääkkeistä on ollut ongelmia ennenkin: jotkut alunperin lääkkeiksi kehitetyt aineet (esim. buprenorfiini) ovat päätyneet päihdekäyttöön ja esim. talidomidin stereoisomeeri aiheutti sikiövaurioita.

"A recent analysis of U.S. Food and Drug Administration (FDA) data and clinical trial data shows that nonbenzodiazepine Z-drugs at prescribed doses cause cancer in humans. The data shows that trial subjects receiving hypnotic drugs had an increased the risk of developing cancer and malignancies. There have been 15 epidemiologic studies which have shown that hypnotic drugs cause increased mortality, mainly due to increased cancer deaths. The cancers included cancer of the brain, lung, bowel, breast, and bladder, and neoplasms. Initially FDA reviewers did not want to approve the drugs due to concerns over cancer but ultimately changed their mind and approved the drugs despite the concerns. FDA data has shown that zolpidem, zaleplon and eszopiclone are clastogenic and cause cancer in rodents. Benzodiazepine agonists are associated with an increased risk of ovarian cancer in humans. Zopiclone was reportedly refused a product license by the FDA in the USA due to indications that zopiclone caused cancer."