sculptra

VAKAVAT Myöhäissivuvaikutukset
Sculptra olisi ollut käytössä Suomessa jo 10 vuotta sitten mutta sen myöhäissivuvaikutusten vuoksi ei kukaan järkevä ja vastuullinen lääkäri käytä tätä tuotetta - tämä on varoituksen sana.

FDA on hyväksynyt sen ainoastaan HIV potilaiden rasvan katoamishoitoon poskien alueella.



Sculptra Side Effects
Injectable poly-L-lactic acid (Sculptra, Dermik Laboratories, Bridgewater, NJ) available in Europe as New-fill since 1999 and in the US market since August 2004 has a significant history of side effects. The early usage of Sculptra was practiced with low volume (2 cc) reconstitution and higher volume of total product injected. This coupled with closely spaced treatment sessions led to frequent nodule formations (Sculptra lumps).
According to Vleggaar, many European injectors rejected this product as high risk for complications. The product is composed of particulate matter - microbeads of PLA and mannitol - which is prone to clump, extrude, and form small nodules even without an adverse host immune response. Lam et al recently published new guidelines for PLA injection: 8-12 cc dilutant (i.e. 5-10 cc sterile water and 2 cc 1% lidocaine with epinephrine) and a minimum of 12 hours for reconstitution. In addition they recommended no more than 2 vials for injection into the subcutaneous fat, and spacing sessions at least 6 weeks apart. These authors in Salyan report granulomatous nodules (Sculptra lumps) in 0.2-12% incidence, which occurs as a delayed hypersensitivity phenomenon.

Poly-L-lactic acid differs from the other fillers in that it is dependent on the host immune/reparative response to accomplish filling. Other similar products include silicone and polymethyl-metracrylate (neither is currently FDA approved for soft tissue augmentation). Unfortunately this mechanism of action for augmentation has two potentially negative effects inherent to the nature of the response: (1) the host immune system can respond less than optimally causing less augmentation then desired; or (2) the host immune system can respond overexuberantly creating granulomas or lumps. In the mouse model histologic evaluations at 1 month has shown: (1) polylactide surrounded by 100 (im thick capsule; (2) mononuclear cells, macrophages, fibroblasts with increased collagen; and (3) mature vascularized fibrous capsule. As reported by Gogoleski et al, at 3 months there are: (1) Decreased cell numbers and increased collagen fibers with a capsule thickness of 80 |J.m. At 6 months the cell numbers decreased and the capsule thickness is only 60 |im. Lemperle studied the histologic reaction in his own forearm to poly-L-lactic acid. At 1 month there was fine capsule around implant. At 3 months the Sculptra microspheres were intact, and surrounded by macrophages and lymphocytes. At 6 months the Sculptra microspheres were degraded and deformed, and surrounded by macrophages and giant cells. At 9 months the Sculptra microparticles completely degraded and there was no detectable scar tissue. Poly-L-lactic acid is a filler in which mechanism of augmentation has been proposed but not proven. Beljaards et al report the histology from side effects or complications has shown fibroblast giant cell granulomas but no new collagen. The immune system has an intergral role in fibroblast behavior so the response to this product in the immune-competent population might be quite different to that of the immunocompromised (HIV) population. The mechanism of augmentation for this product, particularly the short- and long-term tissue effects in immunocompetent patients, needs to be better characterized by further study.

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Tässä linkin sivuvaikutusvisuihin....ylii 10 sivua googlesta...hmm...

http://www.google.fi/search?sourceid=navclient&ie=UTF-8&rlz=1T4SUNA _enFI255FI257&q=sculptra+side-effects

SIVUVAIKUTUKSET kirjoitti:

VAKAVAT Myöhäissivuvaikutukset
Sculptra olisi ollut käytössä Suomessa jo 10 vuotta sitten mutta sen myöhäissivuvaikutusten vuoksi ei kukaan järkevä ja vastuullinen lääkäri käytä tätä tuotetta - tämä on varoituksen sana.

FDA on hyväksynyt sen ainoastaan HIV potilaiden rasvan katoamishoitoon poskien alueella.



Sculptra Side Effects
Injectable poly-L-lactic acid (Sculptra, Dermik Laboratories, Bridgewater, NJ) available in Europe as New-fill since 1999 and in the US market since August 2004 has a significant history of side effects. The early usage of Sculptra was practiced with low volume (2 cc) reconstitution and higher volume of total product injected. This coupled with closely spaced treatment sessions led to frequent nodule formations (Sculptra lumps).
According to Vleggaar, many European injectors rejected this product as high risk for complications. The product is composed of particulate matter - microbeads of PLA and mannitol - which is prone to clump, extrude, and form small nodules even without an adverse host immune response. Lam et al recently published new guidelines for PLA injection: 8-12 cc dilutant (i.e. 5-10 cc sterile water and 2 cc 1% lidocaine with epinephrine) and a minimum of 12 hours for reconstitution. In addition they recommended no more than 2 vials for injection into the subcutaneous fat, and spacing sessions at least 6 weeks apart. These authors in Salyan report granulomatous nodules (Sculptra lumps) in 0.2-12% incidence, which occurs as a delayed hypersensitivity phenomenon.

Poly-L-lactic acid differs from the other fillers in that it is dependent on the host immune/reparative response to accomplish filling. Other similar products include silicone and polymethyl-metracrylate (neither is currently FDA approved for soft tissue augmentation). Unfortunately this mechanism of action for augmentation has two potentially negative effects inherent to the nature of the response: (1) the host immune system can respond less than optimally causing less augmentation then desired; or (2) the host immune system can respond overexuberantly creating granulomas or lumps. In the mouse model histologic evaluations at 1 month has shown: (1) polylactide surrounded by 100 (im thick capsule; (2) mononuclear cells, macrophages, fibroblasts with increased collagen; and (3) mature vascularized fibrous capsule. As reported by Gogoleski et al, at 3 months there are: (1) Decreased cell numbers and increased collagen fibers with a capsule thickness of 80 |J.m. At 6 months the cell numbers decreased and the capsule thickness is only 60 |im. Lemperle studied the histologic reaction in his own forearm to poly-L-lactic acid. At 1 month there was fine capsule around implant. At 3 months the Sculptra microspheres were intact, and surrounded by macrophages and lymphocytes. At 6 months the Sculptra microspheres were degraded and deformed, and surrounded by macrophages and giant cells. At 9 months the Sculptra microparticles completely degraded and there was no detectable scar tissue. Poly-L-lactic acid is a filler in which mechanism of augmentation has been proposed but not proven. Beljaards et al report the histology from side effects or complications has shown fibroblast giant cell granulomas but no new collagen. The immune system has an intergral role in fibroblast behavior so the response to this product in the immune-competent population might be quite different to that of the immunocompromised (HIV) population. The mechanism of augmentation for this product, particularly the short- and long-term tissue effects in immunocompetent patients, needs to be better characterized by further study.

Comments are closed.

Tässä linkin sivuvaikutusvisuihin....ylii 10 sivua googlesta...hmm...

http://www.google.fi/search?sourceid=navclient&ie=UTF-8&rlz=1T4SUNA _enFI255FI257&q=sculptra+side-effects

ei tarvii uskoa eikä tietää mitään.

Hei pirteänaama! Missä kävit Sculptra-hoidossa ja mitä maksoi? Jos ei ollut pk-seudulla niin tiedätkö mistä pk-seudulla voisi hoitoja kysellä?
Kauniiksi ei ihan hinnalla millä hyvänsä....

Jotenkin minusta tuntuu, että lääkärin mielipide ei ole ihan puolueeton... Tuntuu jo hieman mustamaalaamiselta. Olisikohan lääkäri varmaankin puragenin kannattaja??

100 kirjoitti:

Jotenkin minusta tuntuu, että lääkärin mielipide ei ole ihan puolueeton... Tuntuu jo hieman mustamaalaamiselta. Olisikohan lääkäri varmaankin puragenin kannattaja??

Suomenkielinen SCULPTRA nettisivusto on auennut osoitteessa www.sculptra.fi

kun oikein silmin katsotaan, me ollaan lääkäreitä kaikki, ihan jokainen! :)

lääkäri ja asiantunt kirjoitti:

kun oikein silmin katsotaan, me ollaan lääkäreitä kaikki, ihan jokainen! :)

Moikka1 olen ottanut ko ainetta kasvoihini juuri ohimon seudulle ja suupieliin sekä nenänvierusjuonteisiin...monet kyselevät että olenko rakastunut tai muutama kysyi että olenko käynyt kasvojen kohotuksessa..olen saanut juonteita pois ja kasvoissa luonnolisen näköistä täyteläisyyttä..joskus mua on luultu 30v vaikka olen 45v..

kauneus on.. kirjoitti:

Moikka1 olen ottanut ko ainetta kasvoihini juuri ohimon seudulle ja suupieliin sekä nenänvierusjuonteisiin...monet kyselevät että olenko rakastunut tai muutama kysyi että olenko käynyt kasvojen kohotuksessa..olen saanut juonteita pois ja kasvoissa luonnolisen näköistä täyteläisyyttä..joskus mua on luultu 30v vaikka olen 45v..

Onko sinulle tullut mitään muhkuroita tai vastaavaa sculptrasta?