But the actual fact is, that the medical literature doesn’t yet support the belief that 1,25(OH)2D can significantly affect the progression of sarcoidosis. For example, drugs such as ketoconazole, that are able to lower the production of 1,25(OH)2D, have been given to sarcoidosis patients. However, while they are able to reduce the elevated 1,25(OH)2D levels, and decrease hypercalcemia, there is no evidence that they can control any of the other symptoms in sarcoidosis, or the course of the disease. Additionally, lab tests have shown that granuloma formation can occur even in animals lacking the vitamin D receptor (VDR). In fact, the granulomas formed in such animals, were actually significantly larger than in normal animals. Thus, even though elevated vitamin D has known to be associated with sarcoidosis for almost 2 decades, no study has yet proven that 1,25(OH)2D is a major cause of the chronic inflammation seen in sarcoidosis.
Potilaille on annettu ketoconazolea, joka alentaa 1.25 D:tä, mutta sarkoidoosin oireet eivät häviä.
Eläimillä, joilta on hävitetty vit D-reseptori,
eli D-vitamiini ei vaikuta millään tavoin enää,
niin jopa edelleen syntyi granuloomia. Jopa suurempia, kuin normaaleilla sarkoidoosieläimillä. 1.25 D ei ole kroonisen tulehduksen pääsyy sarkoidoosissa.
Medical literature is now starting to document the fact that vitamin D has infection fighting properties. This has long been suspected, given the many studies which showed that tuberculosis is associated with a vitamin D deficiency and VDR mutations. New studies have shown that vitamin D supplementation can help treat tuberculosis. How exactly it helps is unclear, but a recent study has shown that 1,25(OH)2D induces the expression of several antimicrobial substances Additionally, it’s been found that sunlight induces those antimicrobial substances in human skin, via 1,25(OH)2D.
MP believes that the negative effect from 1,25(OH)2D is due to increased inflammation, it actually makes more sense to believe that excess 1,25(OH)2D would have a negative impact on an infection, because it suppresses the immune system, and is suppressing the killing of the pathogens which the MP believes is the cause of the TH1 conditions. This theory makes much more sense, given that 1,25(OH)2D has been shown to have several immunosuppressive properties, and thus can moderate the immune system’s response to infections. Based on this, one could speculate that above normal amounts of 1,25(OH)2D might reduce the effectiveness of the body to fight infections.
But regardless of which theory you believe, there’s still little proof in the medical literature that elevated levels of 1,25(OH)2D could significantly prevent the body from fighting off an infection. And even if it could do this, there’s even less proof that 1,25(OH)2D levels in the normal range, would have such an effect. However, people on the MP are told to avoid vitamin D, no matter what their 1,25(OH)2D levels are.
But perhaps the most important point of why 25(OH)D should not be considered detrimental, is the fact that in many tissues, local production of 1,25(OH)2D may play a significant role in fighting cancer. The 1,25(OH)2D is believed to be derived from 25(OH)D that enters the tissues Serum 1,25(OH)2D is not believed to significantly contribute to this effect, because it’s level is much too low to create the effects necessary to protect the tissues from cancer. To quote from a recent study on breast cells: “1,25(OH)2D interacts with the vitamin D receptor (VDR) to inhibit directly the growth of prostate, colon, and breast cancer cells; however, these growth regulatory effects are observed at concentrations (100 nmol/L) well above the physiologic range that are in fact toxic in vivo. Based on these considerations, it is unlikely that 1,25(OH)2D acts at the systemic level to regulate cell growth in vivo. The identification of CYP27B1 [the enzyme to create 1,25(OH)2D] in skin, colon, prostate, and breast suggests that locally generated 1,25(OH)2D could act in an autocrine manner to protect cells against transformation.” They also excluded the possibility that 25(OH)D had any direct effects on VDRs. “To exclude the possibility that 25(OH)D could directly activate VDR in the absence of metabolism, the effects of 25(OH)D and 1,25(OH)2D on CYP24 protein expression were measured in cells isolated from the mammary gland of CYP27B1 knockout mice. In these cells, 1,25(OH)2D clearly induced CYP24 (indicating the presence of functional VDR) but 25(OH)D did not, indicating that functional CYP27B1 is required for VDR target gene induction by 25(OH)D.”
More and more studies are showing a connection between decreased vitamin D and higher cancer rates. For example, one recent study has shown that breast cancer risk is increased by 3 times in women with 25(OH)D levels less than 20ng/ml. The risk was lower for all groups with higher levels (up to 80ng/ml) The risk increases to almost 7 times, if a person also has a specific VDR gene. VDR genes affect diseases that are significantly influenced by vitamin D, so it is interesting to look to see what genes TH1 conditions are affected by.
Naiset, jotka harkitsette MP hoitoa, tiedoksi D-vitamiinipuutoksen aiheuttama 3-kertainen rintasyöpäriski.
perustuu todennäköisesti melatoniin.
Effect of sunlight on melatonin production is definitely a significant effect. Light suppresses melatonin production, and avoidance of sunshine would raise melatonin production. Melatonin is known to have significant effects on the immune system. Anecdotal reports in the medical literature of sarcoidosis being treated with melatonin have been known for many years, and a 2006 open pilot study has shown that melatonin can indeed be an effective treatment for sarcoidosis.
Melatonin is a potent antioxidant. For example, a recent lab study has shown that it can reduce inflammatory injury from colitis, via the inhibition of NF-kappaB. The MP not only recommends avoiding sunlight, but also recommends wearing noir sunglasses, even indoors. Since melatonin production is mainly affected by exposure of light on the eyes, such a protocol could easily be expected to significantly alter melatonin levels.
Ja kertoo lähteet. Ei pidä levittää varmentamatonta tietoa tai tahallista väärää tietoa olivat ne vaikuttimet miten sairaita tahansa!
...että kun syö vitamiinia liikaa niin voi tulla ns. "heikit housuun"?